Dr. Reynolds: How a detox or cleanse can reduce inflammation and support overall health

by Paul Reynolds, PhD

Inflammation is a natural immune response to injury or infection, but chronic inflammation can lead to various health issues, including autoimmune disorders, cardiovascular diseases, and gastrointestinal (GI) distress. Detox and cleansing programs are often marketed as a way to reduce inflammation by eliminating toxins and promoting better gut health. But what does science say about the relationship between detoxification, inflammation, and overall health?

The link between detoxification and inflammation

Detoxification generally refers to eliminating harmful substances from the body, either exogenous (from outside) or endogenous (produced within). Chronic inflammation often correlates with an imbalance in oxidative stress and the accumulation of reactive oxygen species (ROS), which can harm tissues. 

Detox regimens often aim to address these factors by supporting the body's natural defense systems, such as the liver and GI tract. 

• Antioxidant support: Natural products that boost antioxidant activity can significantly impact inflammation. Compounds like flavonoids and polyphenols from plants can neutralize ROS and modulate inflammatory signaling pathways (Lei et al., 2014). 

• Role of the gut: The gut microbiota is crucial in modulating inflammation. Prebiotics, probiotics, and certain herbal supplements enhance gut barrier integrity, reducing inflammation-related GI issues (Calder et al., 2009).

Herbal ingredients for GI regularity and inflammation

Herbal ingredients are a cornerstone of many detox protocols, offering both anti-inflammatory benefits and support for GI regularity. 

• Senna and cascara sagrada are effective natural laxatives that help eliminate waste and toxins. 

• Ginger, known for its anti-inflammatory properties, also stimulates GI motility, alleviating bloating and enhancing digestion. 

• Turmeric, which contains the active compound curcumin, has potent anti-inflammatory effects that extend beyond the gut to address systemic inflammation. 

• Dandelion root is traditionally used to promote liver detoxification and improve bile production, supporting overall digestive health (Saha et al., 2020).

Evidence supporting detox and inflammation reduction

Research highlights the effectiveness of detoxification strategies in reducing inflammation and improving overall health. 

For instance, antioxidants play a significant role in mitigating oxidative stress, a key driver of chronic inflammation. Consuming a diet rich in antioxidant compounds, such as polyphenols and flavonoids, has been shown to lower inflammatory markers like C-reactive protein, which is often elevated in chronic inflammatory conditions (Nathan, 2002). 

Additionally, the inclusion of anti-inflammatory foods and supplements in the diet can modulate inflammatory responses effectively. Studies indicate that diets low in pro-inflammatory foods, such as those high in refined sugars and processed fats, and enriched with anti-inflammatory ingredients, such as omega-3 fatty acids and plant-based antioxidants, can significantly improve inflammation-related health outcomes. Such dietary approaches offer a sustainable and natural way to support the body's detoxification processes and alleviate chronic inflammation (Shivappa et al., 2018).

Practical takeaways

To effectively manage inflammation and support detoxification, focus first on adopting a nutrient-dense diet rich in antioxidants, prebiotics, and probiotics to enhance natural cleansing processes and reduce inflammatory markers. Maintaining gut health is also essential, as a balanced microbiome plays a crucial role in modulating inflammation and optimizing detoxification pathways.

About the author: Dr. Paul Reynolds earned a Ph.D. in molecular and developmental biology, with his post-doctoral work focusing on pulmonary inflammation. Currently a professor at Brigham Young University, Dr. Reynolds studies inflammation and glycation, specifically how exposure to particulates (personal air pollution) influences health. He frequently publishes scientific reports and presents at meetings on the topics of inflammation during hyperglycemia and how ketogenic states mitigate inflammatory outcomes.